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The research and development plan is focused on the research of new innovative diagnostic and prognostic markers and therapeutic goals in the field of women's cancer, focusing primarily on endometrial cancer and cervical disease using a modern multidisciplinary approach (in addition to the classic biomedical focus, research approaches are also used in the field of materials research/sensors and modern information technologies) and the mutual integration of research and development results.
The project is based on a multidisciplinary approach to the analysis of potential markers of endometrial cancer. The know-how of MGA and its partners is a prerequisite for the successful integration of both clinical, histomorphological, immunohistochemical, genetic, genomic, proteomic, and glycomic analyzes. In the project, we also use new approaches based on innovative biotechnologies (biosensors). Using them, we assume the introduction of a simple method for the analysis of the composition of the microenvironment using changes in the pressure of the interstitial fluid of the tumor. The expected data width requires subsequent intelligent computer analysis. The result of such an analysis should be a predictive model of tumor behavior. The analysis of the prevalence of the HPV population will enable a better understanding of the state of the Slovak population, which is important for the processes of introducing vaccination at present. The application of low-dimensional nanoobjects in biomedicine is an interdisciplinary issue, combining nanotechnology, nanoscience, and materials science with chemistry, biomedicine, and oncology. The presented project also brings input from the field of nanotechnology, nanoscience, and materials science, including advanced experimental methods.
The main scientific goal of the project is to identify markers with a high potential for use in diagnostic practice in healthcare, with the potential to improve diagnostics, prognostic evaluation, as well as to identify potential new therapeutic goals of patients.
By optimizing the diagnosis of the most common uterine tumors using modern diagnostic and laboratory procedures, with regards to possible use in non-invasive diagnostics and with regards to the identification of hereditary forms of tumors, the long-term goal is to reduce the incidence and mortality of the third most common cancer in women. Another scientific goal of the project is to create a model of the origin, behavior, prognosis, and response to endometrial cancer therapy.